{"id":155242,"date":"2026-09-15T09:35:18","date_gmt":"2026-09-15T13:35:18","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//news/news/wp-json/wp/v2/posts/155242//?p=155242"},"modified":"2026-09-15T09:47:14","modified_gmt":"2026-09-15T13:47:14","slug":"ucf-discovery-on-immune-cells-could-illuminate-pathways-to-new-treatments","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//news/news/wp-json/wp/v2/posts/155242//ucf-discovery-on-immune-cells-could-illuminate-pathways-to-new-treatments/news/wp-json/wp/v2/posts/155242//","title":{"rendered":"UCF Discovery on Immune Cells Could Illuminate Pathways to New Treatments"},"content":{"rendered":"<hr>/news/wp-json/wp/v2/posts/155242/n<p>For generations, scientists have looked to the genetics inside immune cells for ways to improve how the body fights disease.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>Now, a <a href=/news/wp-json/wp/v2/posts/155242/"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//research/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242/">research</news/wp-json/wp/v2/posts/155242//a> team led by <a href=/news/wp-json/wp/v2/posts/155242/"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//college/news/wp-json/wp/v2/posts/155242//medicine/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242/">UCF College of Medicine</news/wp-json/wp/v2/posts/155242//a> assistant professor Hung Nguyen is examining an understudied molecule within T cells as a pathway to treatments for cancers, infections and autoimmune disorders.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>Their study, recently published in <em>Trends Open</news/wp-json/wp/v2/posts/155242//em>, focuses on transfer RNA (tRNA), molecules within cells that help build proteins to energize themselves. Nguyen is working to chemically modify these molecules to expand the function of T cells, specialized white blood cells that are the cornerstone of the body/news/wp-json/wp/v2/posts/155242/u2019s immunity. The findings represent an important first step toward understanding whether tRNA can eventually be manipulated to fine-tune immune responses to multiple diseases.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>T cells play a key role in identifying and killing invasive abnormalities within the body, including infections and cancers. The cells also allow the body to remember previous infections and respond more quickly if re-infected or attacked, says Cuong Pham, a <a href=/news/wp-json/wp/v2/posts/155242/"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//degree/news/wp-json/wp/v2/posts/155242//biomedical-sciences-phd/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242/">biomedical sciences Ph.D. candidate</news/wp-json/wp/v2/posts/155242//a> working under Nguyen who served as the study/news/wp-json/wp/v2/posts/155242/u2019s first author.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>/news/wp-json/wp/v2/posts/155242/u201cT cells are already central to modern medicine,/news/wp-json/wp/v2/posts/155242/u201d Pham says. /news/wp-json/wp/v2/posts/155242/u201cAt the same time, we still do not fully understand all the molecular mechanisms that determine how T cells become activated to respond. Our review brings together emerging evidence showing that tRNA modifications can help support and regulate these responses./news/wp-json/wp/v2/posts/155242/u201d</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>This discovery comes as a continuation of Nguyen/news/wp-json/wp/v2/posts/155242/u2019s efforts to find innovative immunotherapies for a wide range of conditions. An early career researcher, Nguyen earned a <a href=/news/wp-json/wp/v2/posts/155242/"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//news/news/wp-json/wp/v2/posts/155242//ucf-reach-for-the-stars-2024-honorees-leading-the-charge-into-the-future/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242/">/news/wp-json/wp/v2/posts/155242/u201cReach for the Stars/news/wp-json/wp/v2/posts/155242/u201d award from UCF in 2024</news/wp-json/wp/v2/posts/155242//a> for his potential for significant impact.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<figure id=/news/wp-json/wp/v2/posts/155242/"attachment_155245/news/wp-json/wp/v2/posts/155242/" style=/news/wp-json/wp/v2/posts/155242/"max-width: 1200px;/news/wp-json/wp/v2/posts/155242/" class=/news/wp-json/wp/v2/posts/155242/"figure float-left/news/wp-json/wp/v2/posts/155242/"><noscript><img 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src=/news/wp-json/wp/v2/posts/155242/"data:image/news/wp-json/wp/v2/posts/155242//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E/news/wp-json/wp/v2/posts/155242/" alt=/news/wp-json/wp/v2/posts/155242/"Man in white lab coat, wearing glasses, holds dropper with red liquid in right hand as another man in lab coat observes./news/wp-json/wp/v2/posts/155242/" srcset=/news/wp-json/wp/v2/posts/155242/"data:image/news/wp-json/wp/v2/posts/155242//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E 1200w/news/wp-json/wp/v2/posts/155242/" sizes=/news/wp-json/wp/v2/posts/155242/"(max-width: 1200px) 100vw, 1200px/news/wp-json/wp/v2/posts/155242/" data-srcset=/news/wp-json/wp/v2/posts/155242/"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//wp-content/news/wp-json/wp/v2/posts/155242//blogs.dir/news/wp-json/wp/v2/posts/155242//20/news/wp-json/wp/v2/posts/155242//files/news/wp-json/wp/v2/posts/155242//2026/news/wp-json/wp/v2/posts/155242//09/news/wp-json/wp/v2/posts/155242//Dr.-Hung-Nguyen-and-Cuong-24.jpg 1200w, https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//wp-content/news/wp-json/wp/v2/posts/155242//blogs.dir/news/wp-json/wp/v2/posts/155242//20/news/wp-json/wp/v2/posts/155242//files/news/wp-json/wp/v2/posts/155242//2026/news/wp-json/wp/v2/posts/155242//09/news/wp-json/wp/v2/posts/155242//Dr.-Hung-Nguyen-and-Cuong-24-300x200.jpg 300w, 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https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//wp-content/news/wp-json/wp/v2/posts/155242//blogs.dir/news/wp-json/wp/v2/posts/155242//20/news/wp-json/wp/v2/posts/155242//files/news/wp-json/wp/v2/posts/155242//2026/news/wp-json/wp/v2/posts/155242//09/news/wp-json/wp/v2/posts/155242//Dr.-Hung-Nguyen-and-Cuong-24-360x240.jpg 360w/news/wp-json/wp/v2/posts/155242/" data-src=/news/wp-json/wp/v2/posts/155242/"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//wp-content/news/wp-json/wp/v2/posts/155242//blogs.dir/news/wp-json/wp/v2/posts/155242//20/news/wp-json/wp/v2/posts/155242//files/news/wp-json/wp/v2/posts/155242//2026/news/wp-json/wp/v2/posts/155242//09/news/wp-json/wp/v2/posts/155242//Dr.-Hung-Nguyen-and-Cuong-24.jpg/news/wp-json/wp/v2/posts/155242/"><figcaption class=/news/wp-json/wp/v2/posts/155242/"figure-caption/news/wp-json/wp/v2/posts/155242/">Biomedical sciences Ph.D. candidate Cuong Pham pipettes a mixture of cells and modifying compounds to test the experimental treatments.</news/wp-json/wp/v2/posts/155242//figcaption></news/wp-json/wp/v2/posts/155242//figure>/news/wp-json/wp/v2/posts/155242/n<h2>An Innovative Approach to Immunity</news/wp-json/wp/v2/posts/155242//h2>/news/wp-json/wp/v2/posts/155242/n<p>UCF/news/wp-json/wp/v2/posts/155242/u2019s research is the first time scientists have tested modifying mitochondrial tRNA in T cells to change their behavior, Nguyen says.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>/news/wp-json/wp/v2/posts/155242/u201cWe are looking at the tRNA modification within T cells that have never been reported,/news/wp-json/wp/v2/posts/155242/u201d he says. /news/wp-json/wp/v2/posts/155242/u201cIn the field, tRNA modification is not so new. For T cells, researchers have been focusing on all the other parts before now./news/wp-json/wp/v2/posts/155242/u201d</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>The discovery came as a result of an <a href=/news/wp-json/wp/v2/posts/155242/"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//news/news/wp-json/wp/v2/posts/155242//ucf-researcher-receives-nih-grant-to-study-diets-role-on-side-effects-of-blood-cancer-treatment/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242/">active project in Nguyen/news/wp-json/wp/v2/posts/155242/u2019s lab</news/wp-json/wp/v2/posts/155242//a> that is examining how diet can affect the immune response in&nbsp; cancer patients.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>/news/wp-json/wp/v2/posts/155242/u201cI wouldn/news/wp-json/wp/v2/posts/155242/u2019t say we found this by accident, but we were very lucky,/news/wp-json/wp/v2/posts/155242/u201d Nguyen says. /news/wp-json/wp/v2/posts/155242/u201cWe examined the mitochondria of the T cell, and we kept looking at all the different layers and targets and then we arrived at the tRNA./news/wp-json/wp/v2/posts/155242/u201d</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>Studying tRNA is challenging because the molecules are short and densely packed, making them difficult to analyze and modify, Nguyen says.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>So the UCF team used cutting edge technology called liquid chromatography-tandem mass spectrometry (LC-MS/news/wp-json/wp/v2/posts/155242//MS). The highly sensitive technique separates massive quantities of molecules in a sample and then identifies and measures them.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>/news/wp-json/wp/v2/posts/155242/u201cIt is very new for use in detecting tRNA, and it was so important for us to see how everything worked,/news/wp-json/wp/v2/posts/155242/u201d Nguyen says.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<figure id=/news/wp-json/wp/v2/posts/155242/"attachment_155244/news/wp-json/wp/v2/posts/155242/" style=/news/wp-json/wp/v2/posts/155242/"max-width: 1200px;/news/wp-json/wp/v2/posts/155242/" class=/news/wp-json/wp/v2/posts/155242/"figure float-left/news/wp-json/wp/v2/posts/155242/"><noscript><img decoding=/news/wp-json/wp/v2/posts/155242/"async/news/wp-json/wp/v2/posts/155242/" width=/news/wp-json/wp/v2/posts/155242/"1200/news/wp-json/wp/v2/posts/155242/" height=/news/wp-json/wp/v2/posts/155242/"800/news/wp-json/wp/v2/posts/155242/" 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src=/news/wp-json/wp/v2/posts/155242/"data:image/news/wp-json/wp/v2/posts/155242//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E/news/wp-json/wp/v2/posts/155242/" alt=/news/wp-json/wp/v2/posts/155242/"Dr. Nguyen stands in center, surrounded by six of his students in courtyard of College of Medicine/news/wp-json/wp/v2/posts/155242/" srcset=/news/wp-json/wp/v2/posts/155242/"data:image/news/wp-json/wp/v2/posts/155242//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E 1200w/news/wp-json/wp/v2/posts/155242/" sizes=/news/wp-json/wp/v2/posts/155242/"(max-width: 1200px) 100vw, 1200px/news/wp-json/wp/v2/posts/155242/" 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https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//wp-content/news/wp-json/wp/v2/posts/155242//blogs.dir/news/wp-json/wp/v2/posts/155242//20/news/wp-json/wp/v2/posts/155242//files/news/wp-json/wp/v2/posts/155242//2026/news/wp-json/wp/v2/posts/155242//09/news/wp-json/wp/v2/posts/155242//Dr.-Nguyen-lab-group-shot-medicine-ucf-360x240.jpg 360w/news/wp-json/wp/v2/posts/155242/" data-src=/news/wp-json/wp/v2/posts/155242/"https:/news/wp-json/wp/v2/posts/155242///news/wp-json/wp/v2/posts/155242//www.ucf.edu/news/wp-json/wp/v2/posts/155242//wp-content/news/wp-json/wp/v2/posts/155242//blogs.dir/news/wp-json/wp/v2/posts/155242//20/news/wp-json/wp/v2/posts/155242//files/news/wp-json/wp/v2/posts/155242//2026/news/wp-json/wp/v2/posts/155242//09/news/wp-json/wp/v2/posts/155242//Dr.-Nguyen-lab-group-shot-medicine-ucf.jpg/news/wp-json/wp/v2/posts/155242/"><figcaption class=/news/wp-json/wp/v2/posts/155242/"figure-caption/news/wp-json/wp/v2/posts/155242/">UCF College of Medicine assistant professor Hung Nguyen (front row, second from left) and his lab team. (Photo by Eddy Duryea &#8217;13)</news/wp-json/wp/v2/posts/155242//figcaption></news/wp-json/wp/v2/posts/155242//figure>/news/wp-json/wp/v2/posts/155242/n<h2>Results Could Impact Other Immunity Research</news/wp-json/wp/v2/posts/155242//h2>/news/wp-json/wp/v2/posts/155242/n<p>In the study, the team genetically engineered the tRNA to give T cells signals to activate against specific disease cells.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>While the research is still in its early stages, Nguyen says that they have already identified ways to modify T cells to pinpoint and fight melanoma, colon cancer and lupus.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>Nguyen says he hopes his new findings will provide a way for other researchers to create new immunotherapies.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>/news/wp-json/wp/v2/posts/155242/u201cWe want to share these ideas with the greater science community and bring everyone together to help us validate them and ultimately benefit more people,/news/wp-json/wp/v2/posts/155242/u201d he says.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>Drawn to UCF for its opportunities for interdisciplinary research, Pham says he/news/wp-json/wp/v2/posts/155242/u2019s looking forward to being a part of what/news/wp-json/wp/v2/posts/155242/u2019s next in the College of Medicine/news/wp-json/wp/v2/posts/155242/u2019s immunology efforts.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>/news/wp-json/wp/v2/posts/155242/u201cThe next step is to move deeper into the mechanisms behind these observations,/news/wp-json/wp/v2/posts/155242/u201d Pham says. /news/wp-json/wp/v2/posts/155242/u201cOur lab has strong and ambitious research directions in immunometabolism. We want to understand how those changes in tRNA influence T cell metabolism and function, and whether specific pathways can eventually be targeted to ultimately help patients./news/wp-json/wp/v2/posts/155242/u201d</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<p>Minh Tuyet Le Nguyen, a UCF postdoctoral scholar, and the Hanoi University of Pharmacy in Vietnam also contributed to the research.</news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n<hr>/news/wp-json/wp/v2/posts/155242/n<p><em>Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R01HL166820. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.</news/wp-json/wp/v2/posts/155242//em></news/wp-json/wp/v2/posts/155242//p>/news/wp-json/wp/v2/posts/155242/n","protected":false},"excerpt":{"rendered":"<p>The findings mark an important first step in understanding how to modify T cells to create future treatments for cancers, infections and autoimmune 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