{"id":149000,"date":"2025-09-18T09:13:03","date_gmt":"2025-09-18T13:13:03","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/149000///news/wp-json/wp/v2/posts/149000//www.ucf.edu/news/wp-json/wp/v2/posts/149000//news/news/wp-json/wp/v2/posts/149000//?p=149000"},"modified":"2025-09-25T11:13:48","modified_gmt":"2025-09-25T15:13:48","slug":"ucf-researchers-fight-breast-prostate-cancer-with-targeted-therapies-backed-by-2-new-grants","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/149000///news/wp-json/wp/v2/posts/149000//www.ucf.edu/news/wp-json/wp/v2/posts/149000//news/news/wp-json/wp/v2/posts/149000//ucf-researchers-fight-breast-prostate-cancer-with-targeted-therapies-backed-by-2-new-grants/news/wp-json/wp/v2/posts/149000//","title":{"rendered":"UCF Researchers Fight Breast, Prostate Cancer with Targeted Therapies Backed by 2 New Grants"},"content":{"rendered":"

A UCF team of researchers is refining its game plan to tackle cancer./news/wp-json/wp/v2/posts/149000/n

Annette Khaled, who leads the College of Medicine/news/wp-json/wp/v2/posts/149000/u2019s cancer research division, recently received more than $2 million in grant funding to expand her work with Z-TOP, a peptide she discovered in 2012 that stops the spread of metastatic cancer cells. She is collaborating with UCF College of Engineering and Computer Science colleagues to design a better cellular delivery system for the treatment./news/wp-json/wp/v2/posts/149000/n

An almost $258,000 grant through the Casey DeSantis Cancer Research Program/news/wp-json/wp/v2/posts/149000/u2019s Florida Cancer Innovation Fund will help Khaled/news/wp-json/wp/v2/posts/149000/u2019s team further their efforts to stop metastatic breast cancer by disrupting the cellular activities that allow cancer cells to spread./news/wp-json/wp/v2/posts/149000/u202fAnd nearly $1.8 million in funding through the U.S. Department of Defense (DOD), in partnership with the Orlando Veterans Affairs Healthcare System, will allow her to develop the treatment for men with late-stage metastatic prostate cancer./news/wp-json/wp/v2/posts/149000/n

Khaled says her research has expanded thanks to the support of the Orlando Sports Foundation, which funds cancer research through sports-related fundraising events. The nonprofit/news/wp-json/wp/v2/posts/149000/u2019s flagship event is the StaffDNA Cure Bowl, a unique college football game with the goal of ending cancer./news/wp-json/wp/v2/posts/149000/n

/news/wp-json/wp/v2/posts/149000/u201cWhen you get funding for a research project, you can only do the work that is described in the specific aims of the project,/news/wp-json/wp/v2/posts/149000/u201d she says. /news/wp-json/wp/v2/posts/149000/u201cThe donations from the Orlando Sports Foundation do not have this limitation./news/wp-json/wp/v2/posts/149000/u202fWithout their support, I would not have been awarded the DOD grant. Using the donations, I was able to generate the preliminary data that made me competitive for the DOD and the Florida Department of Health (FDOH) grants we received this year./news/wp-json/wp/v2/posts/149000/u201d/news/wp-json/wp/v2/posts/149000/n

Alan Gooch /news/wp-json/wp/v2/posts/149000/u201984 /news/wp-json/wp/v2/posts/149000/u201989MA, CEO of the Orlando Sports Foundation and executive director of the StaffDNA Cure Bowl, says he/news/wp-json/wp/v2/posts/149000/u2019s grateful to continue partnering with UCF./news/wp-json/wp/v2/posts/149000/n

/news/wp-json/wp/v2/posts/149000/u201cWe/news/wp-json/wp/v2/posts/149000/u2019re all about bringing teams together,/news/wp-json/wp/v2/posts/149000/u201d says Gooch, who played football at UCF and later coached the team for 22 years. /news/wp-json/wp/v2/posts/149000/u201cOur relationship with Dr. Khaled is outstanding, and we are honored to continue to partner with her and sponsor her research./news/wp-json/wp/v2/posts/149000/u201d/news/wp-json/wp/v2/posts/149000/n

The Science Behind Khaled/news/wp-json/wp/v2/posts/149000/u2019s Work/news/wp-json/wp/v2/posts/149000/n

The two new grants expand Khaled/news/wp-json/wp/v2/posts/149000/u2019s portfolio of research to understand how and why cancer cells spread./news/wp-json/wp/v2/posts/149000/n

/news/wp-json/wp/v2/posts/149000/u201cCancer treatments are very effective when the cancer is localized, but the problem is that cancer doesn/news/wp-json/wp/v2/posts/149000/u2019t stay at one site,/news/wp-json/wp/v2/posts/149000/u201d she says. /news/wp-json/wp/v2/posts/149000/u201cIt spreads to other sites of the body. Usually, the cause of death is not the primary cancer, but metastasis./news/wp-json/wp/v2/posts/149000/u202fPreventing that can be a cancer cure, and that is what we/news/wp-json/wp/v2/posts/149000/u2019re looking at here in our lab./news/wp-json/wp/v2/posts/149000/u201d/news/wp-json/wp/v2/posts/149000/n

Khaled/news/wp-json/wp/v2/posts/149000/u2019s latest research focuses on the spread of cell fragments called extracellular vesicles that are shed by cancer cells during the early stages of the disease. These vesicles are resilient to early cancer treatment and can travel through the bloodstream, acting as tumor /news/wp-json/wp/v2/posts/149000/u201cseeds/news/wp-json/wp/v2/posts/149000/u201d by preparing future sites for metastasis./news/wp-json/wp/v2/posts/149000/n

The vesicles are mediated by a molecular structure called a chaperonin. Chaperonins help fold proteins that support the body/news/wp-json/wp/v2/posts/149000/u2019s normal cell function. But cancer cells hijack the folding process because they need more chaperonins to grow and spread./news/wp-json/wp/v2/posts/149000/n

Khaled/news/wp-json/wp/v2/posts/149000/u2019s breast cancer research project aims to distinguish which chaperonins help facilitate cancer cells’ growth and stop them without harming normal chaperonins. She hopes to develop a treatment that could regularly deliver her peptide to cancer patients to prevent metastasis. Patients, Khaled says, could receive her treatment while they are receiving chemotherapy and radiation to kill the original tumor./news/wp-json/wp/v2/posts/149000/n

Her prostate cancer research will confirm the chaperonin as a viable treatment target for prostate cancer, and if so, optimize the peptide specifically for use in men who have lethal forms of metastatic prostate cancer./news/wp-json/wp/v2/posts/149000/u202fUnlike breast cancer treatment, which seeks to prevent metastasis, prostate cancer research will see if a strengthened variant of the peptide can eliminate cancer that has already spread./news/wp-json/wp/v2/posts/149000/n