Annette Khaled, second from right, stands with UCF students and collaborators at the Orlando Sports Foundation/news/wp-json/wp/v2/posts/149000/u2019s Kickoff to Cure fundraising event./news/wp-json/wp/v2/posts/149000/nFielding a Team Against Cancer/news/wp-json/wp/v2/posts/149000/n In the lab, Khaled/news/wp-json/wp/v2/posts/149000/u2019s peptide has shown success in preventing cancer cells from spreading. The challenge is how to engineer and deliver the treatment. For that, she is collaborating with Lorraine Leon, associate professor of materials science at UCF/news/wp-json/wp/v2/posts/149000/u2019s College of Engineering and Computer Science./news/wp-json/wp/v2/posts/149000/n
They are working to create a system that delivers the peptide to where the cancer has spread and at the same time protects the peptide from being destroyed in the bloodstream by the body/news/wp-json/wp/v2/posts/149000/u2019s immune and digestive systems./news/wp-json/wp/v2/posts/149000/n
/news/wp-json/wp/v2/posts/149000/u201cThe College of Engineering and Computer Science is a great collaborator,/news/wp-json/wp/v2/posts/149000/u201d Khaled says. /news/wp-json/wp/v2/posts/149000/u201cNormally this peptide is very fragile but we/news/wp-json/wp/v2/posts/149000/u2019re working with materials sciences to create a protected peptide and then find [a] way to get it to the right spot. By having a variety of expertise and interests, we can work together to find new technologies and new ways to combat cancer./news/wp-json/wp/v2/posts/149000/u201d/news/wp-json/wp/v2/posts/149000/n
Leon specializes in biomaterials and polymer science. Her team studies how to build and program molecules to form assemblies for many purposes, including biomedical transport. She developed a specialized polymer that binds to the peptide, forming a large, water-soluble molecule. This allows it to travel easily through the bloodstream while keeping the peptide intact as it reaches its destination. The system drives the molecules to form self-assembled structures called micelles, which are assemblies of around 100 or so individual molecules, Leon says./news/wp-json/wp/v2/posts/149000/n
/news/wp-json/wp/v2/posts/149000/u201cIn addition, we can tune the shape of these micelles, decorate them with targeting elements and make mixed versions of them where we incorporate different functionalities,/news/wp-json/wp/v2/posts/149000/u201d she says. /news/wp-json/wp/v2/posts/149000/u201cOur original designs have had great preliminary results so far. We will continue to optimize the designs moving forward./news/wp-json/wp/v2/posts/149000/u201d/news/wp-json/wp/v2/posts/149000/n
Leon is excited to team up with Khaled, and she says she looks forward to achieving more breakthroughs together as the projects progress./news/wp-json/wp/v2/posts/149000/n
/news/wp-json/wp/v2/posts/149000/u201cWorking with Dr. Khaled has been very fun,/news/wp-json/wp/v2/posts/149000/u201d she says. /news/wp-json/wp/v2/posts/149000/u201cOur labs really complement each other. This is the beginning of a very long collaboration./news/wp-json/wp/v2/posts/149000/u201d/news/wp-json/wp/v2/posts/149000/n
Khaled and Leon are also working with Cancer Specialist and Associate Professor of Medicine Deborah Altomare, along with Burnett School of Biomedical Science Biostatistician Xiang Zhu, on the prostate cancer research project./news/wp-json/wp/v2/posts/149000/n
Khaled says strong research and community collaborations are critical to beating cancer./news/wp-json/wp/v2/posts/149000/n
/news/wp-json/wp/v2/posts/149000/u201cCancer is a tough enemy,/news/wp-json/wp/v2/posts/149000/u201d she says. /news/wp-json/wp/v2/posts/149000/u201cBut we have a great team./news/wp-json/wp/v2/posts/149000/u201d/news/wp-json/wp/v2/posts/149000/n
These studies are the first phase of preclinical research that may lead to new drugs in the future./news/wp-json/wp/v2/posts/149000/n
This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, in the amount of $1,771,271, through the Prostate Cancer Research Program Idea Development Award under Award No. HT9425-25-1-0487. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Department of Defense./news/wp-json/wp/v2/posts/149000/nResearchers/news/wp-json/wp/v2/posts/149000/u2019 Credentials:/news/wp-json/wp/v2/posts/149000/n Khaled joined UCF in 2002 after receiving her doctoral degree from the University of Florida and doing post-graduate training at the National Cancer Institute (NCI). A tenured professor, she has been funded by multiple R01 grants from the National Institutes of Health, the Breast Cancer Research Foundation and the FDOH. She has published more than 100 manuscripts and abstracts and presented her research at numerous national and international scientific meetings. She has been recognized with research, leadership and teaching awards, including the NCI CURE Lifetime Achievement Award. In addition to her research responsibilities, she teaches molecular immunology to UCF graduate students and serves as the College of Medicine/news/wp-json/wp/v2/posts/149000/u2019s assistant dean for faculty affairs./news/wp-json/wp/v2/posts/149000/n
Leon joined UCF in 2017 after postdoctoral appointments at the University of Chicago and Argonne National Laboratory, and she received her doctoral degree from the City University of New York. She is a recently tenured professor in the Department of Materials Science and Engineering, where she also serves as the education director for the U.S. National Science Foundation PREM Center for Quantum Materials Innovation and Education Excellence. She has published more than 20 refereed publications. Other accomplishments include her being named a 2019 Emerging Investigator by the Journal of Materials Chemistry B, receiving an NSF CAREER award in 2021 and a 3M Non-Tenured Faculty award in 2022./news/wp-json/wp/v2/posts/149000/n","protected":false},"excerpt":{"rendered":"
Strengthened by community and engineering partnerships, Annette Khaled furthers her work with the promising peptide Z-TOP that disrupts cancer cells to keep them from spreading./news/wp-json/wp/v2/posts/149000/n","protected":false},"author":8698,"featured_media":149004,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,12,17,23,24],"tags":[14946,653,54254,973,979,16611,14916],"tu_author":[],"class_list":["post-149000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-health","category-medicine","category-research","category-science-technology","tag-annette-khaled","tag-burnett-school-of-biomedical-sciences","tag-cancer-research-division","tag-college-of-engineering-and-computer-science","tag-college-of-medicine","tag-department-of-materials-science-and-engineering","tag-research"],"yoast_head":"/news/wp-json/wp/v2/posts/149000/n
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